The impact of sinusitis on dose distribution in a radiotherapy plan by in silico study.

OBJECTIVES: To assess the impact of changes in sinus aeration on dose variation in nasopharyngeal cases using a single beam with various field sizes and real patient computed tomography (CT) images. METHODS: The calculations were carried out on a computer equipped with an Intel Xeon (R) Gold 5118 processor operating at 2.30 GHz in 2022 at Taibah University, Al Madinah Al Munawwarah for a retrospective nasopharyngeal case. At the patient level, the impact on dose distribution was examined for different field sizes by comparing the percentage depth dose. The dose discrepancy was evaluated by comparing the dose delivered without considering the anatomical changes observed in the initial fraction to the dose adjusted to account for these changes using a 2D gamma analysis. With a criterion of 1% dose difference and 1 mm distance to agreement, the gamma level for analysis was set at 95%. RESULTS: The study findings indicated that the observed effect diminished by approximately 50% for both 5 cm x 5 cm and 10 cm x 10 cm field sizes compared to the 3 cm x 3 cm size, where there was an overlap between the planning target volume and sinusitis. CONCLUSION: The study concluded that the impact of dose discrepancy was more pronounced in smaller field sizes.

A Cross-Sectional Study on the Knowledge, Attitudes, and Oral Hygiene Practices of Secondary School Students in Al-Qunfudah District, Saudi Arabia.

Background Oral health is closely related to general health awareness and good oral hygiene practices, which makes it an important aspect of general health and well-being. The current study assessed the knowledge, attitudes, and practices of oral hygiene among secondary school students in Al-Qunfudah district, Saudi Arabia. Methods A convenient sample of 383 male and female secondary school students in the Al-Qunfudah district, Saudi Arabia, was included in this descriptive cross-sectional study. The research data were collected from the study sample through a self-administered online survey via WhatsApp and Telegram electronic applications. Finally, the collected data were coded and analyzed through the Statistical Package for the Social Sciences (SPSS) version 25.0 (SPSS Inc., Chicago, IL) and expressed in frequencies, percentages, mean, and standard deviation. The chi-squared and Fisher's exact tests were applied to assess the relationship between the participants' knowledge and practice scores of oral hygiene and their demographic characteristics. A P-value of less than 0.05 was regarded as significant. Results In this study, female students represented 70% of the sample, and most of them were Saudi (97.0%). Many of them identified the great impact of oral hygiene on overall health (89.2%), and more than two-thirds indicated that brushing their teeth regularly would prevent oral problems (89.2%). Nearly two-thirds of them perceived that dental problems would affect their school attendance; however, 59.1% ignored the important role of schools in maintaining students' oral hygiene. The poor practice of dental care was observed among students, as 47.5% brush their teeth twice daily and a third replace their brushes every three months. Despite the fact that the majority of the study population had adequate knowledge (44.4%) and a positive attitude (78.6%) toward oral hygiene, only 39.9% could effectively apply it. The knowledge of oral hygiene was significantly better among females (P = 0.005), older students (P = 0.001), those at a higher academic level (P = 0.016), and students from Al-Qunfudah city (P = 0.007). Furthermore, older pupils, those with a higher academic level, and those from Al-Qunfudah city performed better in terms of dental hygiene than their peers (P-value was 0.001 for each). Conclusion  Secondary school students generally have adequate awareness levels and positive attitudes toward oral hygiene, but they practice it with remarkably little consistency. Schools should emphasize their crucial roles in enhancing oral health among their students of different education levels through their curriculum and frequent monitoring of students. Persuasive and realistic oral health education initiatives are recommended for schoolchildren and their family members or caregivers, with a particular emphasis on males, younger children, and those living in rural areas.

Exploring the attitudes and practices of female doctors towards cervical cancer screening in primary health care centers.

Cervical cancer is a significant cause of female mortality worldwide, and early detection through regular screening is crucial for reducing mortality rates. However, in developing countries, the uptake of Pap smear tests (PST) is low, mostly due to cultural and social factors and a lack of knowledge. This cross-sectional study assessed knowledge, attitude, and practice of cervical cancer screening among practitioners working at primary healthcare centers in Saudi Arabia. Furthermore, the study aimed to identify the potential barriers that prevent female physicians from performing cervical cancer screening tests. A self-administrated, well-structured questionnaire was used to survey 95 female physicians, including residents, specialists, and consultants in several primary health care centers (PHCCs) in Jeddah managed by the Ministry of Health during September 2019. The results showed that 80% of participants knew about cervical cancer, and 97.8% were aware that PST is a screening tool. However, only 47% advised female patients to get tested for cervical cancer. The factors identified as barriers to test uptake included asymptomatic females (34%), lack of time on the part of the practitioner (24%), and a lack of evidence for risk factors (23%). Additionally, only 42.2% of the participating physicians had undergone a Pap smear test themselves. The study highlights the need for further research to assess HPV status in the population and explore the correlation between circumcision and cervical cancer, as well as polygamy and cervical cancer. The findings suggest that while a good level of knowledge about cervical cancer exists, there is a need to improve compliance with cervical cancer screening guidelines among female physicians in Saudi Arabia.

Enhancing Cu2+ Ion Removal: An Innovative Approach Utilizing Modified Frankincense Gum Combined with Multiwalled Carbon Tubes and Iron Oxide Nanoparticles as Adsorbent.

Aquatic pollution, which includes organic debris and heavy metals, is a severe issue for living things. Copper pollution is hazardous to people, and there is a need to develop effective methods for eliminating it from the environment. To address this issue, a novel adsorbent composed of frankincense-modified multi-walled carbon nanotubes (Fr-MMWCNTs) and Fe3O4 [Fr-MWCNT-Fe3O4] was created and subjected to characterization. Batch adsorption tests showed that Fr-MWCNT-Fe3O4 had a maximum adsorption capacity of 250 mg/g at 308 K and could efficiently remove Cu2+ ions over a pH range of 6 to 8. The adsorption process followed the pseudo-second-order and Langmuir models, and its thermodynamics were identified as endothermic. Functional groups on the surface of modified MWCNTs improved their adsorption capacity, and a rise in temperature increased the adsorption efficiency. These results highlight the Fr-MWCNT-Fe3O4 composites' potential as an efficient adsorbent for removing Cu2+ ions from untreated natural water sources.

Impact of a Preparatory Year Programme on the Students of Health Professions Education Colleges: Perception of students and faculty members.

Objectives: The preparatory year programme (PYP) at King Abdulaziz University, Jeddah, Saudi Arabia, is a one-year programme for students preparing for a full multi-year degree curriculum at a university. It offers a bridge between high-school and university-level studies of the students. This study aimed to evaluate the impact of the King Abdulaziz University PYP on students of the health professions education colleges from the viewpoints of the students and the faculty. Methods: This descriptive study was conducted between May 2019 and January 2020 at King Abdulaziz University, in Jeddah, Saudi Arabia and was based on data collected from both students and faculty to assess their perceptions. The data were collected from students through self-administered questionnaires and from faculty members through structured interviews. Descriptive statistics were used for analysis. Results: A total of 633 students responded to the questionnaire (response rate: 88.3%), of which almost half agreed that the PYP made them self-confident and reinforced their discipline (49.2% and 46.9%, respectively). Less than two-thirds agreed that the preparatory year reinforced their sense of responsibility and helped them adapt to the university educational environment (60.6% and 64.3%, respectively). Conversely, more than half (58.5%) disagreed that the preparatory year classes helped them select their majors as well as that the preparatory year prepared them for their major classes (57.2%). A total of 24 faculty members who taught PYP students claimed that there should be careful consideration of the contents of the courses offered to the students in the preparatory year programme, especially the content related to the healthcare profession education. They argued that it is better to have a separate track in the PYP that includes subjects directly related to the study of health professions (such as molecular sciences, genetics, medical terminology, English for medical purposes, etc.). Conclusion: The impact of the PYP on students attending the health professions colleges was found to be weak as per the perceptions of both students and faculty members. In-depth studies are necessary for further investigation of this impact.

Application of a multilayer physical model for the critical analysis of the adsorption of nicotinamide and propranolol on magnetic-activated carbon.

The paper describes a theoretical analysis of the adsorption of nicotinamide and propranolol onto a magnetic-activated carbon (MAC). For a better evaluation of the adsorption mechanism, adsorption isotherms expressing the variation of the adsorption capacity as function of adsorbate concentration were determined at different temperatures ranging from 20 to 45 °C. For both the analytes, experimental tests reveal that adsorption capacity increases with temperature. An advanced multi-layer model derived from the statistical physics is set for the interpretation of the entire adsorption data set. The modelling results show that the propranolol molecules change their adsorption orientation from a mixed (parallel and non-parallel) orientation to a multimolecular process. For nicotinamide, the aggregation of molecules is practically absent, except for the data at lower temperatures. The model allows stating that the adsorption of both the pharmaceutical compounds occurs via the formation of one or two layers on MAC adsorbent, the propranolol showing a higher tendency to form multiple layers. Finally, adsorption energy is estimated suggesting that the adsorption is endothermic and physical interactions are the responsible of the adsorption of both the compounds onto MAC adsorbent.

Development of photoluminescent, superhydrophobic, and electrically conductive cotton fibres.

A simple method for the preparation of multifunctional nanocomposite was developed towards the production of water-repellent, electrically conductive, and photoluminescent film onto cotton fibres. The nanocomposite was composed of lanthanide-doped strontium aluminium oxide and silicon rubber dispersed in petroleum ether. The electrically conductive fabric was woven from nickel strips twisted with cotton filaments as core yarns, which were wrapped with pure cotton yarns. The nanoparticles (NPs) of lanthanide-doped strontium aluminium oxide were mixed with environmentally friendly room-temperature vulcanizing silicon rubber (RTV-SR) dissolved in petroleum ether to give the silicon rubber/strontium aluminate nanocomposites. The produced nanocomposites were applied onto electrically conductive cotton/nickel fibres using spray-coating technology. The surface of the cotton/nickel fibres showed different hierarchical morphologies depending on the total content of the silicon rubber. Additionally, the superhydrophobic effect was found to be improved upon increasing the total content of the luminescence pigment NPs. The morphologies of the prepared phosphor NPs were determined using transmission electron microscopy (TEM). The generated transparent luminescence film demonstrated an absorbance peak at 358 nm and an emission peak at 515 nm. Photoluminescence of cotton fibres was monitored with the generation of different colours, including grey, green-yellow, bright white, and turquoise shades as recognized using CIE Laboratory colorimetric parameters. The emission, excitation, lifetime, and decay time spectra of the phosphorescent spray-coated cotton samples were studied. The surface morphologies and chemical compositions of the spray-coated cotton/nickel were investigated using wavelength-dispersive X-ray fluorescence (WD-XRF), scanning electron microscope (SEM), Fourier-transform infrared spectra (FTIR), and energy-dispersive X-ray analyzer (EDAX). The superhydrophobic effects were characterized by measuring static water contact angle. The comfort characteristics of the treated cotton/nickel substrates were assessed by investigating their air permeability and stiffness. The treated cotton/nickel fabrics also displayed an antimicrobial activity. The results displayed water repellence with high electrical conductivity and photoluminescence properties.

Hepatitis C virus infection in Jeddah city, Saudi Arabia: Seroprevalence and knowledge.

The infection rate of the hepatitis C virus (HCV) in Saudi Arabia is among the lowest in the world. However, it is likely that poor knowledge and awareness of HCV infection could minimize the effectiveness of prevention and control programs in the kingdom. Thus, the study objective was to estimate the prevalence of HCV infection, and to assess current knowledge about it, in the targeted population. Data on 5482 Saudi people attending primary healthcare centers in Jeddah City in 2014/2015 were analyzed in this cross-sectional study. Questions that covered the natural history, risk behavior, and prevention, and treatment of HCV were collected using a predesigned questionnaire. HCV seroprevalence was assessed using an enzyme-linked immunosorbent assay. HCV prevalence of 0.38% (95% confidence interval: 0.22-0.54) was found. The level of knowledge of the natural history, risk behavior, and prevention and treatment of HCV was poor among the participants. The lowest level of knowledge for all participants pertained to its prevention and treatment. The prevalence of HCV was low in Saudi Arabia (0.38%). However, adequate knowledge of HCV was lacking. Thus, the need to increase knowledge and awareness of HCV in the Saudi population is warranted.

Prevalence and predictors of hepatitis B in Jeddah City, Saudi Arabia: a population-based seroprevalence study.

INTRODUCTION: Despite solid preventive strategies to reduce the risk of hepatitis B virus (HBV) infection, recent reports about its prevalence and predictors are lacking in several Saudi cities at the community level. This study aimed to assess the seroprevalence of HBV and to identify the most important predictors among the Saudi population in Jeddah city, Saudi Arabia. METHODOLOGY: A cross-sectional study was conducted among 5,584 Saudi people attending primary health-care centers in Jeddah city during 2012/2013. Sociodemographic and hepatitis-related data were collected. HBV was diagnosed by ELISA test. The seroprevalence of HBV was estimated, and appropriate statistical analyses were performed, including univariate and multivariable regression analyses. RESULTS: The seroprevalence of HBV was 2.2% (95% CI = 1.82-2.58) in the studied participants. The prevalence was higher among non-governmental workers (3.5%), male participants (3.4%) and those aged ≥ 25 years (2.4%). The most important predictors for increasing the risk of HBV in this study were HBV contacts, male sex, history of dental procedures and blood transfusion. The significant positive risks associated with these predictors were 3.3, 2.5, 2.0 and 1.65, respectively. HBV vaccination, on the other hand, was associated with a significant risk reduction of 88% (OR = 0.12; 95% CI = 0.03-0.51). CONCLUSIONS: The seroprevalence of HBV was relatively low among the Saudi population in Jeddah city reflecting the actions taken by health authorities to control HBV infection. However, more efforts, particularly in relation to health education programmes, strict control of blood banks and dental clinics, are still needed.